CHLORPHENAMINE = CHLORPHENIRAMINE oral


Therapeutic action

– Sedating H1 antihistamine

Indications

– Symptomatic treatment of minor allergic reactions (urticaria, allergic conjunctivitis, etc.)

Forms and strengths

– 2 mg/5 ml oral solution
– 4 mg tablet

Dosage

– Child 1 to < 2 years: 1 mg 2 times daily
– Child 2 to < 6 years: 1 mg 4 to 6 times daily (max. 6 mg daily)
– Child 6 to < 12 years: 2 mg 4 to 6 times daily (max. 12 mg daily)
– Child ≥ 12 years and adult: 4 mg 4 to 6 times daily (max. 24 mg daily; max.12 mg daily in elderly patients)

Age

Weight

2 mg/5 ml oral solution

4 mg tablet

1 to < 2 years

10 to < 13 kg

2.5 ml x 2

2 to < 6 years

13 to < 21 kg

2.5 ml x 4

6 to < 12 years

21 to < 39 kg

5 ml x 4

½ tab x 4

≥ 12 years and adult

≥ 39 kg

1 tab x 4

Duration

– As short as possible (a few days).

Contra-indications, adverse effects, precautions

– Administer with caution and monitor use:
• in children and elderly patients (risk of agitation, excitability);
• in patients with prostate disorders, closed-angle glaucoma, epilepsy, severe renal or hepatic impairment;
• in patients taking central nervous system depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, etc.) or drugs known to have an anticholinergic effect (atropine, amitriptyline, chlorpromazine, etc.).
– May cause: 
• drowsiness, dizziness, headache, confusion, hypotension, photosensitivity (protect skin from sun exposure); rarely: extrapyramidal syndrome, allergic reactions;
• anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition).
– Avoid alcohol during treatment.
– Pregnancy and breast-feeding
• Prefer loratadine as from the 2nd trimester of pregnancy and in lactating women
• If no alternative is available and treatment is clearly needed, administer chlorphenamine 
for as short a time as possible. Monitor the child (risk of sedation and anticholinergic effects) if the mother was treated just before birth or if she is breast-feeding.  

Remarks

– Chlorphenamine is less sedating than promethazine.
  Storage: below 25 °C -  -