SPECTINOMYCIN injectable

Prescription under medical supervision


Cephalosporins are the first choice treatment of gonococcal infections. Spectinomycin may be used as an alternative, when cephalosporins are not available or are contra-indicated.


Therapeutic action

– Antibacterial (group of aminoglycosides)

Indications

– Second choice treatment of gonococcal infections

Forms and strengths, route of administration

– Powder for injection in 2 g vial, to be dissolved with the diluent supplied by the manufacturer (3.2 ml ampoule of water for injection with benzyl alcohol), for IM injection

Dosage and duration

– Anogenital gonococcal infection and gonococcal conjunctivitis
Adult: 2 g single dose (a dose of 4 g may be required, i.e. 2 g in each buttock)

– Disseminated gonococcal infection
Adult: 2 g every 12 hours for 7 days

Contra-indications, adverse effects, precautions

– May cause: nausea, dizziness, fever and chills, urticaria; pain at injection site.
– PregnancyCONTRA-INDICATED (safety is not established)
– Breast-feeding: no contra-indication for a single dose treatment

Remarks

– Administer a concurrent anti-chlamydia treatment to patients with gonococcal infections (co-infections are frequent).
– Spectinomycin is poorly effective against pharyngeal gonococcal infections.
– For the treatment of neonatal gonococcal conjunctivitis, use cephalosporins.
– Shake well prior to withdrawal medication and use a 19G needle.
– Do not mix with other drugs in the same syringe.
– Storage: below 25 °C