Most HIV-positive children with TB respond well to the 6-month TB regimen, similar to HIV-uninfected children. If the clinical response is slow, other causes should be considered such as poor adherence to therapy, inadequate drug absorption, DR-TB, and other infections.
The following ARV regimens are preferred in children on TB treatment:
– Child < 3 years old or < 10 kg: AZT preferred or D4T/3TC + ABC;
– Child > 3 years and > 10 kg: AZT preferred or ABC or D4T/3TC + EFV.
TDF is considered safe in children above 3 years of age.