16.1 Isoniazid preventive therapy (IPT)


IPT (or isoniazid prophylaxis) is most often the treatment for primary infection in order to sterilize lesions and prevent the development of active tuberculosis (TB). It is more a treatment than a prophylaxis.

It consists of the daily administration of isoniazid (H) for 6 months, at a dose of1:

Isoniazid PO:
Newborns and children less than 30 kg: 10 mg/kg once daily (7 to 15 mg/kg/day)
Children over 30 kg and adults: 5 mg/kg once daily (4 to 6 mg/kg/day)
Maximum dose: 300 mg/day