Amoxicillin/Clavulanic acid (Amx/Clv)

Therapeutic action

– Antibacterial (penicillin) with possible bactericidal activity

Presentation

– 875 mg amoxicillin/125 mg clavulanic acid tablet (ratio 7:1)
– 400 mg amoxicillin/57 mg clavulanic acid/5 ml, powder for oral suspension (ratio 7:1)
– 500 mg amoxicillin/62.5 mg clavulanic acid tablet (ratio 8:1)
– 500 mg amoxicillin/62.5 mg clavulanic acid/5 ml, powder for oral suspension (ratio 8:1)

Dosage (expressed in amoxicillin)

– Child and adult: 80 mg/kg/day in 2 divided doses
– Maximum dose: 3000 mg daily
– Patient with severe renal impairment: 1000 mg/day in 2 divided doses

Weight
(kg)

Daily dose
(mg)

875 mg/125 mg
tablet

400 mg/57 mg per 5 ml
oral suspension

5

400

2.5 ml x 2

6

480

3 ml x 2

7

560

3.5 ml x 2

8

640

4 ml x 2

9

720

4.5 ml x 2

10

800

5 ml x 2

11

880

5.5 ml x 2

12

960

6 ml x 2

13

1040

6.5 ml x 2

14

1120

7 ml x 2

15

1200

7.5 ml x 2

16

1280

8 ml x 2

17

1360

8.5 ml x 2

18

1440

9 ml x 2

19

1520

9.5 ml x 2

20

1600

10 ml x 2

21

1680

1 tab x 2

22

1760

1 tab x 2

23

1840

1 tab x 2

24

1920

1 tab x 2

25

2000

1 tab x 2

26

2080

1 tab (morning) + 1 ½ tab (evening)

27

2160

1 tab (morning) + 1 ½ tab (evening)

28

2240

1 tab (morning) + 1 ½ tab (evening)

29

2320

1 tab (morning) + 1 ½ tab (evening)


30-35

2600

1 tab (morning) + 2 tab (evening)

36-45

2600

1 tab (morning) + 2 tab (evening)

46-55

2600

1 tab (morning) + 2 tab (evening)

56-70

2600

1 tab (morning) + 2 tab (evening)

> 70

2600

1 tab (morning) + 2 tab (evening)

Contra-indications, adverse effects, precautions

– Do not administer to patients with history of allergy to penicillins or hepatic disorders during a previous treatment with amoxicillin/clavulanic acid.
– Administer with caution to patients with hepatic impairment or history of allergy to cephalosporins (cross-sensitivity may occur).
– May cause: diarrhoea, hypersensitivity reactions, jaundice and cholestatic hepatitis.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Monitoring

– Symptomatic monitoring

Patient instructions

– Take with food.

Remarks

– The ratio of amoxicillin/clavulanic acid varies according to the manufacturer (2/1, 4/1, 6/1, 8/1, 7/1, 14/1, 16/1). The daily dose and administration schedule may vary depending on the formulation used.
 Storage: below 25°C - 
Powder for oral suspension: between 15°C and 25°C - 
Once reconstituted, the oral suspension must be kept refrigerated (between 2°C and 8°C) and may be used for up to 7 days.