Amoxicillin/clavulanic acid ratio 4:1 (Amx/Clv)

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Update: January 2022

Child under 30 kg: 3 mg (0.25 ml)/kg of clavulanic acid 3 times daily, 60 minutes before each dose of meropenem
Adolescent ≥ 15 years and ≥ 30 kg and adult: 125 mg of clavulanic acid 2 times daily, 60 minutes before each dose of carbapenem
Maximum dose: 250 mg daily

Weight (kg)	Daily dose (mg)	500 mg/125 mg tablet	250 mg/62.5 mg per 5 ml oral suspension
5	50	−	1.3 ml x 3
6	60	−	1.5 ml x 3
7	70	−	2 ml x 3
8	80	−	2 ml x 3
9	90	−	2.5 ml x 3
10	100	−	2.5 ml x 3
11	110	−	3 ml x 3
12	120	−	3 ml x 3
13	130	−	3.5 ml x 3
14	140	−	3.5 ml x 3
15	150	−	4 ml x 3
16	160	−	4.5 ml x 3
17	170	−	4.5 ml x 3
18	180	−	5 ml x 3
19	190	−	5 ml x 3
20	200	−	5.5 ml x 3
21	210	−	5.5 ml x 3
22	220	−	6 ml x 3
23	230	−	6 ml x 3
24	240	−	6.5 ml x 3
25	250	−	6.5 ml x 3
26	250	−	6.5 ml x 3
27	250	−	6.5 ml x 3
28	250	−	6.5 ml x 3
29	250	−	6.5 ml x 3

30-35	250	1 tab x 2	−
36-45	250	1 tab x 2	−
46-55	250	1 tab x 2	−
56-70	250	1 tab x 2	−
> 70	250	1 tab x 2	−

Do not administer to penicillin-allergic patients and patients with history of hepatic disorders during a previous treatment with amoxicillin/clavulanic acid.
Administer with caution to patients with hypersensitivity to other betalactams (cross-hypersensitivity may occur) and to patients with hepatic impairment.
May cause: gastrointestinal disturbances (mainly diarrhoea), hypersensitivity reactions, hepatotoxicity.
For the management of adverse effects, see Appendix 17.
Pregnancy: no contra-indication
Breastfeeding: no contra-indication

–

– Below 25 °C

Powder for oral suspension: between 15 °C and 25 °C
Once reconstituted, the oral suspension must be kept refrigerated (between 2 °C and 8 °C) and may be used for up to 7 days.