Ethambutol (E)

Therapeutic action

– Antibacterial with bacteriostatic activity

Presentation

– 100 mg and 400 mg tablets

Dosage

– Child under 30 kg: 20 mg/kg (15 to 25 mg/kg) once daily
– Child over 30 kg and adult: 15 mg/kg (15 to 25 mg/kg) once daily
– Maximum dose: 1200 mg daily
– Patient with renal impairment: 15 to 25 mg/kg/dose, 3 times per week

Weight
(kg)

Daily dose
(mg)

400 mg
tablet

100 mg
tablet

5

75-125

1 tab

6

90-150

1 tab

7

105-175

1 tab

8

120-200

½ tab

9

135-225

½ tab

10

150-250

½ tab

11

165-275

½ tab

12

180-300

½ tab

13

195-325

½ tab

14

210-350

3 tab

15

225-375

3 tab

16

240-400

3 tab

17

255-425

3 tab

18

270-450

1 tab

19

285-475

1 tab

20

300-500

1 tab

21

315-525

1 tab

22

330-550

1 tab

23

345-575

1 tab

24

360-600

1 tab

25

375-625

1 tab

26

390-650

1 tab

27

405-675

1½ tab

28

420-700

1½ tab

29

435-725

1½ tab


30-35

600

1½ tab

36-45

800

2 tab

46-55

1000

2 tab

56-70

1200

3 tab

> 70

1200

3 tab

Contra-indications, adverse effects, precautions

– Do not administer to patients with severe renal impairment or pre-existing optic neuritis (e.g. diabetic retinopathy).
– May cause: retrobulbar optic neuritis.
– The dosage must be carefully adjusted to the weight (adverse effects are dose-dependant), especially for children under 5 years, as it is more difficult to detect visual alterations at this age.
– For the management of adverse effects, see Appendix 10.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Monitoring

– Visual acuity and colour discrimination before and during treatment

Patient instructions

– Take with or without food.

Remarks

– For patients on first-line treatment, ethambutol is given as part of a fixed dose combination.
 Storage: below 25°C -  -