Ofloxacin (Ofx)

Therapeutic action

– Antibacterial (fluoroquinolone) with bactericidal activity

Presentation

– 200 mg and 400 mg tablets

Dosage

– Child under 30 kg: 15 to 20 mg/kg/day in 2 divided doses
– Child over 30 kg and adult: 800 mg/day in 2 divided doses
– Maximum dose: 800 mg daily
– Patient with severe renal impairment: 600 to 800 mg/dose, 3 times per week

Weight
(kg)

Daily dose
(mg)

400 mg
tablet

200 mg
tablet

5

75-100

6

90-120

7

105-140

8

120-160

9

135-180

10

150-200

½ tab x 2

11

165-220

½ tab x 2

12

180-240

½ tab x 2

13

195-260

½ tab x 2

14

210-280

½ tab x 2

15

225-300

1 tab (morning) + ½ tab (evening)

16

240-320

1 tab (morning) + ½ tab (evening)

17

255-340

1 tab (morning) + ½ tab (evening)

18

270-360

1 tab (morning) + ½ tab (evening)

19

285-380

1 tab (morning) + ½ tab (evening)

20

300-400

1 tab x 2

21

315-420

1 tab x 2

22

330-440

1 tab x 2

23

345-460

1 tab x 2

24

360-480

1 tab x 2

25

375-500

1 tab x 2

26

390-520

1 tab x 2

27

405-540

1 tab x 2

28

420-560

1 tab x 2

29

435-580

1 tab x 2


30-35

800

1 tab x 2

36-45

800

1 tab x 2

46-55

800

1 tab x 2

56-70

800

1 tab x 2

> 70

800

1 tab x 2

Contra-indications, adverse effects, precautions

– Do not administer to patients with history of allergy or tendon damage during a previous treatment with a fluoroquinolone.
– Administer with caution to children, adolescents and patients over 60 years (increased risk of tendon damage); patients with risk factors for QT interval prolongation (heart failure, bradycardia, hypokalaemia, etc.) or history of psychiatric disorders or seizures.
– May cause: gastrointestinal disturbances, headache, central nervous system disorders (dizziness, insomnia, depression, etc.), hypersensitivity reaction, photosensitivity, peripheral neuropathy, myalgia, tendinitis, tendon rupture; rarely, crystalluria.
– Avoid or monitor combination with drugs that prolong QT interval (amiodarone, bedaquiline, clofazimine, erythromycin, fluconazole, lopinavir, mefloquine, ondansetron, pentamidine, quinine, etc.) and warfarin.
– For the management of adverse effects, see Appendix 10.
– Do not administer simultaneously with antacids containing magnesium or aluminium, calcium, iron and zinc salts, didanosine (except enteric-coated formulation): administer 2 hours apart.
Pregnancy and breastfeeding: safety is not established, considered as acceptable when vital for the mother.

Monitoring

– Symptomatic monitoring

Patient instructions

– May be taken with food but do not take milk-based product and antacids and multivitamins when taking a tablet, wait two hours.
– Maintain a good fluid intake.
– Protect your skin from sun.

Remarks

Storage: below 25°C