Pyrazinamide (Z)

Therapeutic action

– Antibacterial with sterilising and bactericidal activity

Presentation

– 400 mg tablet

Dosage

– Child under 30 kg: 35 mg/kg (30 to 40 mg/kg) once daily
– Child over 30 kg and adult: 25 mg/kg (20 to 30 mg/kg) once daily
– Maximum dose: 2000 mg daily
– Patient with renal impairment: 25 mg/kg/dose, 3 times per week

Weight
(kg)

Daily dose
(mg)

400 mg
tablet

5

150-200

½ tab

6

180-240

½ tab

7

210-280

½ tab

8

240-320

¾ tab

9

270-360

¾ tab

10

300-400

1 tab

11

330-440

1 tab

12

360-480

1 tab

13

390-520

1 tab

14

420-560

1 tab

15

450-600

1½ tab

16

480-640

1½ tab

17

510-680

1½ tab

18

540-720

1½ tab

19

570-760

1½ tab

20

600-800

1½ tab

21

630-840

2 tab

22

660-880

2 tab

23

690-920

2 tab

24

720-960

2 tab

25

750-1000

2 tab

26

780-1040

2 tab

27

810-1080

2 tab

28

840-1120

2½ tab

29

870-1160

2½ tab


30-35

800

2 tab

36-45

1000

2½ tab

46-55

1200

3 tab

56-70

1600

4 tab

> 70

2000

5 tab

Contra-indications, adverse effects, precautions

– Do not administer to patients with history of allergy to pyrazinamide, severe hepatic impairment or severe gout.
– May cause: gout and arthralgias, hepatic disorders, photosensitivity, rash, gastrointestinal disturbances, hypersensitivity reactions.
– For the management of adverse effects, see Chapter 9 and Appendix 10.
Pregnancy: safety in the first trimester is not definitely established. However, given the severity of the disease, it may be used during pregnancy.
Breast-feeding: no contra-indication

Monitoring

– Symptomatic monitoring

Patient instructions

– Take with or without food.
– Protect your skin from sun.

Remarks

– For patients on first-line treatment, pyrazinamide is given as part of a fixed dose combination.
 Storage: below 25°C -  -