Acknowledgements
Foreword
Abbreviations and acronyms
Chapter 1: Introduction and epidemiology
Chapter 2: Clinical presentation
Chapter 3: Diagnosis and follow-up investigations
Chapter 4: Diagnosis of active tuberculosis in children
Chapter 5: Diagnostic algorithm for pulmonary tuberculosis in symptomatic adolescents and adults
Chapter 6: Screening for active tuberculosis
Chapter 7: Case definitions
Chapter 8: Tuberculosis drugs and treatment regimens
Chapter 9: Treatment of drug-susceptible tuberculosis
Chapter 10: Treatment of multidrug-resistant and rifampicin-resistant tuberculosis
Chapter 11: Treatment of rifampicin-susceptible and isoniazid-resistant tuberculosis
Chapter 12: Tuberculosis and HIV co-infection
Chapter 13: Adherence to tuberculosis treatment
Chapter 14: Infection prevention and control
Chapter 15: Follow-up of staff exposed to tuberculosis
Chapter 16: Treatment of latent tuberculosis infection
Chapter 17: Monitoring and evaluation
Appendices
- Appendix 1. Xpert assays
- Appendix 2. Interpretation of Xpert assay results
- Appendix 3. Collection, storage, and shipment of respiratory specimens
- Appendix 4. Sputum smear microscopy
- Appendix 5. Time required for diagnostic test results
- Appendix 6. Ventilated workstation and biosafety cabinet
- Appendix 7. Lymph node fine needle aspiration
- Appendix 8. Protein estimation
- Appendix 9. Tuberculin skin test
- Appendix 10. Drug information sheets and patient instructions for active TB treatment
- Appendix 11. TB drugs in pregnant or breastfeeding women
- Appendix 12. Dose adjustments in renal insufficiency
- Appendix 13. Daily dose of TB drugs using fixed-dose combinations
- Appendix 14. Monitoring of patients on DS-TB treatment
- Appendix 15. Monitoring of patients on DR-TB treatment
- Appendix 16. Additional investigations in DR-TB
- Appendix 17. Management of adverse effects
  - Gastrointestinal disorders
  - Nervous system and psychiatric disorders
  - Endocrine disorders
  - Skin and subcutaneous tissue disorders
  - Musculoskeletal disorders
  - Miscellaneous
- Appendix 18. Compassionate use of TB drugs
- Appendix 19. Drug interactions and overlapping toxicities
- Appendix 20. Treatment supporters
- Appendix 21. Therapeutic patient education
- Appendix 22. Assessment of adherence to TB treatment
- Appendix 23. Basic tool for assessing risk of TB transmission
- Appendix 24. Recommendations for air change per hour
- Appendix 25. Overview of ventilation techniques
- Appendix 26. Germicidal ultraviolet lamps
- Appendix 27. Respirators
- Appendix 28. Surgical masks
- Appendix 29. BCG vaccine
- Appendix 30. DS-TB and Hr-TB treatment card
- Appendix 31. DS-TB and Hr-TB register
- Appendix 32. MDR/RR-TB treatment card
- Appendix 33. MDR/RR-TB register
- Appendix 34. Request form for smear microscopy and Xpert assays
- Appendix 35. Request form for culture, pDST, LPA, genome sequencing
- Appendix 36. Drug-o-gram
- Appendix 37. Case detection and enrolment report and treatment outcome report
- Appendix 38. TB facility assessment sheet

Nervous system and psychiatric disorders