المحتويات
Update: October 2022
Forms and strengths
- 300 mg and 150 mg coated tablets
Dosage
-
Child 12 years and over and adult 40 kg and over: 1200 mg once daily
|
Age |
Daily dose (mg) |
300 mg tablet |
|---|---|---|
|
< 12 years |
Do not administer |
− |
|
≥ 12 years |
1200 |
4 tab |
Contra-indications, adverse effects, precautions
- Do not administer to patients with hypersensitivity reaction or severe haematologic disorders (thrombocytopenia, purpura) during a previous treatment with a rifamycin.
- Avoid or administer with caution to patients with hepatic disorders.
- May cause:
- hepatotoxicity;
- influenza-like symptoms, thrombocytopenia, hypersensitivity reactions.
- For the management of adverse effects, see Appendix 17.
- Rifapentine reduces the effect of many drugs (antimicrobials, some antiretrovirals, some hormones, antidiabetics, corticosteroids, phenytoin, direct-acting antivirals for chronic hepatitis C, warfarin, etc.):
- in patients taking antiretrovirals, see Appendix 19;
- in women using contraception, use injectable medroxyprogesterone or an intrauterine device;
- in the event of concomitant fluconazole administration, administer each drug 12 hours apart (rifampicin in the morning, fluconazole in the evening);
- for the other drugs, adjust dosage if necessary.
- Pregnancy and breastfeeding: not recommended (safety not established).
Monitoring
- Symptomatic monitoring.
- Liver function in patients with hepatic disease.
Patient instructions
- Take with food.
- Harmless orange-red discoloration of the urine, faeces, sweat, saliva, sputum, tears and other body fluids.
Remarks
- While rifampicin should be taken on an empty stomach, rifapentine is better absorbed if taken with food.
- Also comes in fixed-dose combination containing 300 mg of rifapentine/300 mg of isoniazid which can be used in the treatment regimen 2HPZ-Mfx/2HP-Mfx for drug-susceptible TB.
- Rifapentine is also used in the treatment of latent TB infection.
Storage
–
– Below 25 °C