Pretomanid (Pa)

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المحتويات

    Update: October 2022

     

    Forms and strengths

    • 200 mg tablet

    Dosage

    • Adolescent 15 years and over and adult:  200 mg once daily, in combination with :
      • bedaquiline, linezolid and moxifloxacin (BPaLM) 
      • bedaquiline, linezolid and clofazimine (BPaLC)   
      • bedaquiline and linezolid (BPaL) 
    • Maximum dose:  200 mg daily  

     

    Age 

    Daily dose (mg) 

    200 mg tablet 

    < 15 years 

    Do not administer 

    − 

    ≥ 15 years 

    200 

    1 tab

     

    Contra-indications, adverse effects, precautions

    • Do not administer if one of the drugs included in the regimen is contra-indicated.  
    • The contribution of pretomanid to the adverse effects of pretomanid-containing regimens is not determined. 
    • For adverse effects of companion drugs, see individual drug information sheets. 
    • Pregnancy: use only if benefits outweigh the risks (safety not established). 
    • Breastfeeding: avoid breastfeeding during treatment (safety not established).

    Monitoring

    • Symptomatic monitoring.

    Patient instructions

    • Take with food.

    Storage

     
    –  
     
    – 
    Below 25 °C 
    Path