AMOXICILLIN oral

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    Last updated: April 2024

     

    Prescription under medical supervision

     

    Therapeutic action

    • Penicillin antibacterial

    Indications

    • Acute otitis media, streptococcal tonsillitis, sinusitis, bronchitis, pneumonia with no signs of severity
    • Infection due to Helicobacter pylori (in combination with omeprazole and clarithromycin), leptospirosis, uncomplicated cutaneous anthrax
    • Uncomplicated typhoid fever if the strain is susceptible (recent drug susceptibility test)
    • Completion treatment following therapy with parenteral penicillins or cephalosporins

    Forms and strengths

    • 250 mg and 500 mg tablets or capsules
    • 250 mg dispersible scored tablet, for paediatric use
    • 125 mg/5 ml powder for oral suspension:
      • to be reconstituted with filtered water
      • to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)

    Dosage

    Usual dosage (e.g. leptospirosis, tonsillitis, infection due to H. pylori)

    • Child: 25 mg/kg (max. 1 g) 2 times daily 
    • Adult: 1 g 2 times daily

     

    Age

    Weight

    Daily dose

    125 mg/5 ml susp.

    250 mg tablet

    500 mg tablet

    < 3 months

    < 6 kg

    125 mg x 2

    5 ml x 2

    ½ tab x 2

    3 to < 24 months

    6 to < 12 kg

    250 mg x 2

    10 ml x 2

    1 tab x 2

    2 to < 8 years

    12 to < 25 kg

    500 mg x 2

    20 ml x 2

    2 tab x 2

    1 tab x 2

    ≥ 8 years and adult

    ≥ 25 kg

    1 g x 2

    4 tab x 2

    2 tab x 2

     

    High dosage (e.g. pneumonia, typhoid fever, resistant pneumococcal infections, cutaneous anthrax)

    • Child: 30 mg/kg (max. 1 g) 3 times daily
    • Adult: 1 g 3 times daily

     

    Age

    Weight

    Daily dose

    125 mg/5 ml susp.

    250 mg tablet

    500 mg tablet

    < 3 months

    < 6 kg

    125 mg x 3

    5 ml x 3

    ½ tab x 3

    3 to < 24 months

    6 to < 12 kg

    250 mg x 3

    10 ml x 3

    1 tab x 3

    2 to < 8 years

    12 to < 25 kg

    500 mg x 3

    20 ml x 3

    2 tab x 3

    1 tab x 3

    ≥ 8 years and adult

    ≥ 25 kg

    1 g x 3

    4 tab x 3

    2 tab x 3

     

    Duration

    • Otitis media, bronchitis, pneumonia: 5 days
    • Tonsillitis: 6 days
    • Leptospirosis, H. pylori infection: 7 days
    • Sinusitis: 7 to 10 days
    • Cutaneous anthrax: 7 to 14 days depending on severity
    • Typhoid fever: 14 days

    Contra-indications, adverse effects, precautions

    • Do not administer to penicillin-allergic patients or patients with mononucleosis.
    • Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
    • May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event of allergic reaction, stop treatment immediately.
    • Reduce dosage in patients with severe renal impairment.
    • Do not combine with methotrexate.
    • Pregnancy and breast-feeding: no contra-indication

    Storage

     
    –  
     
    –  Below 25 °C 
     
    For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.