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Therapeutic action
- Penicillin antibacterial
Indications
- Acute otitis media, streptococcal tonsillitis, sinusitis, bronchitis, pneumonia with no signs of severity
- Infection due to Helicobacter pylori (in combination with omeprazole and clarithromycin), leptospirosis, uncomplicated cutaneous anthrax
- Uncomplicated typhoid fever if the strain is susceptible (recent drug susceptibility test)
- Completion treatment following therapy with parenteral penicillins or cephalosporins
Forms and strengths
- 250 mg and 500 mg tablets or capsules
- 250 mg dispersible scored tablet, for paediatric use
- 125 mg/5 ml powder for oral suspension:
- to be reconstituted with filtered water
- to be administered using a measuring device (oral syringe, measuring spoon, or cup with graduations)
Dosage
Usual dosage (e.g. leptospirosis, tonsillitis, infection due to H. pylori)
- Child: 25 mg/kg (max. 1 g) 2 times daily
- Adult: 1 g 2 times daily
|
Age |
Weight |
Daily dose |
125 mg/5 ml susp. |
250 mg tablet |
500 mg tablet |
|---|---|---|---|---|---|
|
< 3 months |
< 6 kg |
125 mg x 2 |
5 ml x 2 |
½ tab x 2 |
– |
|
3 to < 24 months |
6 to < 12 kg |
250 mg x 2 |
10 ml x 2 |
1 tab x 2 |
– |
|
2 to < 8 years |
12 to < 25 kg |
500 mg x 2 |
20 ml x 2 |
2 tab x 2 |
1 tab x 2 |
|
≥ 8 years and adult |
≥ 25 kg |
1 g x 2 |
– |
4 tab x 2 |
2 tab x 2 |
High dosage (e.g. pneumonia, typhoid fever, resistant pneumococcal infections, cutaneous anthrax)
- Child: 30 mg/kg (max. 1 g) 3 times daily
- Adult: 1 g 3 times daily
|
Age |
Weight |
Daily dose |
125 mg/5 ml susp. |
250 mg tablet |
500 mg tablet |
|---|---|---|---|---|---|
|
< 3 months |
< 6 kg |
125 mg x 3 |
5 ml x 3 |
½ tab x 3 |
– |
|
3 to < 24 months |
6 to < 12 kg |
250 mg x 3 |
10 ml x 3 |
1 tab x 3 |
– |
|
2 to < 8 years |
12 to < 25 kg |
500 mg x 3 |
20 ml x 3 |
2 tab x 3 |
1 tab x 3 |
|
≥ 8 years and adult |
≥ 25 kg |
1 g x 3 |
– |
4 tab x 3 |
2 tab x 3 |
Duration
- Otitis media, bronchitis, pneumonia: 5 days
- Tonsillitis: 6 days
- Leptospirosis, H. pylori infection: 7 days
- Sinusitis: 7 to 10 days
- Cutaneous anthrax: 7 to 14 days depending on severity
- Typhoid fever: 14 days
Contra-indications, adverse effects, precautions
- Do not administer to penicillin-allergic patients or patients with mononucleosis.
- Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
- May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event of allergic reaction, stop treatment immediately.
- Reduce dosage in patients with severe renal impairment.
- Do not combine with methotrexate.
- Pregnancy and breast-feeding: no contra-indication
Storage
–
– Below 25 °C
For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.