11.7 Adverse effects

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    Rapid management of adverse effects is essential to increase tolerance and improve outcomes.

    • In the event of minor adverse effects, drugs should not be stopped. Providing support and using ancillary medicines is all that is necessary.
    • In the event of major adverse effects, the regimen may need to be adapted.

     

    Table 11.1 – Main adverse effects and likely responsible drugs 

     

    Adverse effects 

    Drug(s) likely responsible 

    Management 

    Minor  

    Nausea, vomiting  

    Z, Lzd

    Appendix 17  

    Arthralgia  

    Z 

    		 Appendix 17

    Peripheral neuropathy  

    H, Lzd, Lfx

    		 Appendix 17

    Orange/red urine, tears, etc.  

    R

    		 Patients should be told before starting treatment that this is normal.

    Major  

    Skin reactions  

    E, Z, R, H, Lfx, Lzd, Dlm

    Appendix 17  

    Hepatotoxicity 

    Z, H, R

    Appendix 17 

    Optic neuritis  

    Lzd, E

    		 Appendix 17

    Haematologic disorders  

    Lzd, R, H, E

    		 Appendix 17

     

    For more information on individual drugs, see Appendix 10.

     

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