8.2 Standard code for treatment regimens

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    8.2.1 Tuberculosis drugs

    Each TB drug has an abbreviation.

     

    Table 8.1 – Categories and abbreviations of TB drugs

     

    Categories

    TB drugs

    Abbreviations

    Drug-susceptible TB (first-line drugs)

     

    Isoniazid (standard dose)

    Rifampicin

    Pyrazinamide

    Ethambutol

    Rifabutin

    Rifapentine

    H

    R

    Z

    E

    Rfb

    P

    Drug-resistant TB (second-line drugs)

    Group A

    Levofloxacin or moxifloxacin

    Bedaquiline

    Linezolid

    Lfx or Mfx

    Bdq

    Lzd

    Group B

    Clofazimine

    Cycloserine or terizidone

    Cfz

    Cs or Trd

    Group C

     

     

    Delamanid

    Ethambutol

    Pyrazinamide

    Imipenem/cilastatin or meropenem

    Amikacin or streptomycin

    Ethionamide or prothionamide

    Para-aminosalicylate sodium or para-aminosalicylic acid

    Isoniazid (high-dose)

    Dlm

    E

    Z

    Ipm/Cln or Mpm

    Am or S

    Eto or Pto

    PAS

    Hh

    Ungrouped

    Pretomanid

    Pa

     

    Notes:

    • High-dose isoniazid, although not a Group C drug according to the WHO classification, is considered in this guide as a Group C drug as it is used as such when building a treatment regimen for DR-TB.
    • Pretomanid is not categorized in the WHO classification and is only used in standard treatment regimens for DR-TB (Chapter 10).

    8.2.2 Treatment regimens

    TB treatment regimens are expressed as follows:

    • Drugs are designated by their abbreviation.
    • For some regimens, the treatment is divided into two phases: initial (or intensive) phase, and continuation phase. The phases are separated by a slash /.
    • Letters in brackets ( ) indicate fixed-dose combinations (FDCs).
    • Letters that are not in brackets indicate individual drugs.
    • Second-line drugs are separated by a hyphen.
    • Letters in square brackets [ ] indicate that drugs are used, but not considered as likely effective (Chapter 10).
    • A superscript h (h) indicates that the drug is administered in a high dose.
    • Numbers before letters indicate the duration (in months) of the treatment or of each phase.
    • Numbers in subscript and angle brackets < > after a drug indicate the duration (in months) of the treatment with this drug.

     

    Box 8.1 – Examples

     

    2(HRZE)/4(HR): the initial phase lasts 2 months with an FDC containing 4 drugs; the continuation phase lasts 4 months, with an FDC containing 2 drugs.

     

    18Bdq-Lzd-Cfz-Cs-Dlm-[Z]: the treatment lasts 18 months with 6 individual drugs; Z is used, but not considered as a likely effective drug.

     

    4Bdq<6>-Lfx-Cfz-Z-E-Hh-Lzd<2>/5Lfx-Cfz-Z-E: the initial phase lasts 4 months but bedaquiline is given for 6 months and linezolid for 2 months only; the continuation phase lasts 5 months.