Lactic acidosis

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    Lzd
     

    Lactic acidosis is a rare but potentially life-threatening increase of lactic acid in the bloodstream, that can be due to mitochondrial toxicity of certain TB drugs, usually Lzd.
    Signs and symptoms include nausea and vomiting, abdominal pain, extreme fatigue, muscle cramps and increased respiratory rate.

     

    If lactic acidosis is suspected, measure blood lactate and pH. Blood lactate ≥ 4 mmol/litre and pH < 7.35 confirm the diagnosis. Stop Lzd and hospitalise for adequate management.

     

    Note that lactic acidosis may also be due to ART (NRTIs).

     

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