Contenido
Update: February 2025
Forms and strengths
- 600 mg tablet (breakable and non-breakable)
- 150 mg dispersible tablet
- 100 mg/5 ml, granules for oral suspension
Dosage
- Child under 15 kg: 15 mg/kg once daily
- Child 15 to 45 kg: 10 to 12 mg/kg once daily
- Patient 46 kg and over: 600 mg once daily
- Maximum dose: 600 mg daily
For BPaLM and endTB regimens, these doses are administered as above for 16 weeks.
After 16 weeks:
- Child: the dose is administered 3 times a week (Monday/Wednesday/Friday), instead of once daily, until the end of treatment.
- Adult: the dose is reduced to 300 mg once daily or administered 3 times a week, instead of once daily, until the end of treatment.
Weight (kg) | Daily dose (mg) | 600 mg tablet | 150 mg dispersible tablet | 100 mg per 5 ml oral suspension |
|---|---|---|---|---|
| 5 | 75 | – | – | 3 ml |
| 6 | 90 | – | – | 4 ml |
| 7 | 105 | – | – | 5 ml |
| 8-9 | 120-135 | – | – | 6 ml |
| 10-15 | 150-180 | – | 1 tab | – |
| 16-23 | 160-276 | – | 1½ tab | – |
| 24-29 | 240-348 | – | 2 tab | – |
| ||||
| 30-35 | 300 | – | 2 tab | – |
| 36-45 | 450 | – | 3 tab | – |
| 46-55 | 600 | 1 tab | – | – |
| 56-70 | 600 | 1 tab | – | – |
| > 70 | 600 | 1 tab | – | – |
- Alternatively, for children 5 to 6 kg, if oral suspension is not available: one half of a 150 mg dispersible tablet (75 mg) once daily.
- If 150 mg dispersible tablets are not available, 600 mg tablets can be crushed and suspended in 10 ml of water or fruit juice to obtain a solution of 60 mg of linezolid per ml, administered as follows:
Weight (kg) | Daily dose (mg) | 600 mg tablet in 10 ml (60 mg/ml) |
|---|---|---|
| 5 | 75 | 1.25 ml |
| 6 | 90 | 1.5 ml |
| 7-9 | 105-135 | 2 ml |
| 10-15 | 150-180 | 2.5 ml |
Contra-indications, adverse effects, precautions
- Administer with caution to patients with haematologic disorders or hypertension.
- May cause:
- anaemia, neutropenia and/or thrombocytopenia;
- lactic acidosis;
- peripheral neuropathy (can be irreversible); rarely, optic neuritis;
- abdominal pain, diarrhoea, nausea;
- hypersensitivity reactions.
- For the management of adverse effects, see Appendix 17.
- Avoid or monitor combination with serotonergic drugs such as tricyclic antidepressants (e.g. amitriptyline) or selective serotonin reuptake inhibitors (e.g. fluoxetine, paroxetine): risk of serotonin syndrome.
- Administer concomitantly pyridoxine (vitamin B6); child: 1 to 2 mg/kg (usual range: 10 to 50 mg) once daily; adult: 100 mg once daily.
- Pregnancy: use if the benefits outweigh the risks (safety not established). Administer pyridoxine to the mother (as above).
- Breastfeeding: avoid breastfeeding during treatment (safety not established).
Monitoring
- Symptomatic monitoring.
- Full blood count.
- Visual acuity and colour discrimination.
Patient instructions
- Take with or without food.
Storage
–
– Below 25 °C
Once reconstituted, the oral suspension may be kept at room temperature for 21 days, protected from light.