Appendix 13. Daily dose of TB drugs using fixed-dose combinations

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    Update: October 2022

     

    13.1 Conventional regimens for drug-susceptible TB 

    Intensive phase

    Weight

    (kg)

    		 Paediatric formulations Adult formulations

    HZR

    50/150/75 mg

    E

    100 mg

    E

    400 mg

    H

    100 mg

    EHZR

    275/75/400/150 mg
    4-7 1 tab 1 tab − − − 
    8-11 2 tab 2 tab − − − 
    12-13 3 tab 2 tab − − − 
    14-15 3 tab 3 tab − − − 
    16-17 4 tab 3 tab − − − 
    18-22 4 tab − 1 tab − −
    23-29 − − − 1 tab 2 tab

     
    30-34 − − − − 2 tab
    35-39 − − − −

    2½ tab
    40-54 − − − − 3 tab
    55-70 − − − − 4 tab
    > 70 − − − − 4 tab

     

    For example: 

    • A child weighing 9 kg takes 2 tablets of HZR (50 mg/150 mg/75 mg) + 2 tablets of E (100 mg) once daily. 

    • A child weighing 20 kg takes 4 tablets of HZR (50 mg/150 mg/75 mg) + 1 tablet of E (400 mg) once daily. 

     

    Note: ethambutol is not routinely given to all children: see Chapter 9.

    Continuation phase

    Weight

    (kg)

    		    Paediatric formulation

    HR 50/75 mg

    Adult formulation

    HR 75/150 mg
    4-7 1 tab − 
    8-11 2 tab − 
    12-14 3 tab − 
    15-21 − 2 tab 
    22-29 − 3 tab

     
    30-34 − 2 tab
    35-39 − 3 tab
    40-54 − 3 tab
    55-70 − 4 tab
    > 70 − 4 tab

     

    TB drugs

    Daily dosing in patients < 30 kg 

    Daily dosing in patients ≥ 30 kg 

    E 

    15 to 25 mg/kg 

    15 to 25 mg/kg

    H 

    7 to 15 mg/kg

    4 to 6 mg/kg

    Z 

    30 to 40 mg/kg

    20 to 30 mg/kg

    R 

    10 to 20 mg/kg

    8 to 12 mg/kg

     

    13.2 2HPZ-Mfx/2HP-Mfx regimen for drug-susceptible TB

    Weight

    (kg) 

    HP

    300/300 mg

    P

    300 mg

    Z

    400 mg

    Mfx

    400 mg

    40-49 

    1 tab 

    3 tab 

    4 tab 

    1 tab 

    50-64 

    1 tab 

    3 tab 

    4 tab 

    1 tab 

    ≥ 65 

    1 tab 

    3 tab 

    5 tab 

    1 tab 

     

     

    TB drugs

    Daily dosing in patients < 40 kg

    Daily dosing in patients ≥ 40 kg

    H 

    –

    300 mg 

    Z 

    		 –

    1600 to 2000 mg 

    P 

    		 –

    1200 mg 

    Mfx 

    		 –

    400 mg  
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