9.7 Adverse effects

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Rapid management of adverse effects is essential to increase tolerance and improve outcomes.

  • In the event of minor adverse effects, drugs should not be stopped. Providing support and using ancillary medicines is all that is necessary.
  • In the event of major adverse effects, the regimen may need to be adapted.

 

Table 9.5  Main adverse effects and likely responsible drugs

 

Adverse effects

Drug(s) likely responsible

Management

Minor

Nausea, vomiting

Eto, Z

Appendix 17

Arthralgia

Z

Appendix 17

Peripheral neuropathy

H, Eto

Appendix 17

Orange/red urine, tears, etc.

R, P

Patients should be told before starting treatment that this is normal.

Major

Skin reactions

E, Z, R, H, P, Mfx, Eto

Appendix 17

Hepatotoxicity

Z, H, R, P, Eto

Appendix 17

Optic neuritis

E

Appendix 17

Haematologic disorders

R, P, H, E

Appendix 17

 

For more information on individual drugs, see Appendix 10.