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Rapid management of adverse effects is essential to increase tolerance and improve outcomes.
- In the event of minor adverse effects, drugs should not be stopped. Providing support and using ancillary medicines is all that is necessary.
- In the event of major adverse effects, the regimen may need to be adapted.
Table 9.5 – Main adverse effects and likely responsible drugs
|
Adverse effects |
Drug(s) likely responsible |
Management |
|---|---|---|
|
Minor |
||
|
Nausea, vomiting |
Eto, Z |
|
|
Arthralgia |
Z |
Appendix 17 |
|
Peripheral neuropathy |
H, Eto |
Appendix 17 |
|
Orange/red urine, tears, etc. |
R, P |
Patients should be told that this is normal before starting treatment. |
|
Major |
||
|
Skin reactions |
E, Z, R, H, P, Mfx, Eto |
Appendix 17 |
|
Hepatotoxicity |
Z, H, R, P, Eto |
Appendix 17 |
|
Optic neuritis |
E |
Appendix 17 |
|
Haematologic disorders |
R, P, H, E |
Appendix 17 |
For more information on individual drugs, see Appendix 10.