SODIUM CHLORIDE 0.9% = NaCl 0.9%

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    Last updated: February 2025

     

    Indications

    • Vehicle for the administration of drugs by IV infusion
    • Severe dehydration, fluid replacement in trauma, surgery, anaesthesia (preferably use of Ringer lactate for these indications)

    Forms and strengths

    • 100 ml, 250 ml, 500 ml and 1000 ml bottles or bags

    Composition

    • Isotonic solution of sodium chloride (0.9 g per 100 ml) for infusion
    • Ionic composition:

    sodium (Na+)   150 mmol  (150 mEq) per litre

    chloride (Cl–)   150 mmol  (150 mEq) per litre

    Contra-indications, adverse effects, precautions

    • Administer with caution to patients with conditions associated with sodium or fluid retention (hypertension, heart failure, peripheral or pulmonary oedema, renal impairment, hepatic impairment with cirrhosis, pre-eclampsia, etc.) or to taking drugs that increase the risk of sodium or fluid retention (e.g. corticosteroids).
    • May cause: pulmonary oedema in the event of too rapid infusion or infusion of excessive amounts.
    • Do not use as vehicle for the administration of amphotericin B (incompatibility): use only 5% glucose solution.

    Remarks

    • After infusion, NaCl 0.9% remains in the intravascular compartment for 1 to 2 hours.
    • For correction of hypovolaemia due to haemorrhage, administer 3 times the lost volume only if:
      • blood loss does not exceed 1500 ml in adults;
      • cardiac and renal function are not impaired.
    • 0.9% sodium chloride solution may be used to prevent hypotension induced by spinal anaesthesia.
    • For external use: sterile 0.9% sodium chloride solution is used for cleansing of non-infected wounds, wound irrigation, eye cleansing (conjunctivitis, eye irrigations), nasal lavage in the event of obstruction, etc.

    Storage

    Below 25 °C

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