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Update: January 2022
Forms and strengths
- 400 mg tablet
- 150 mg dispersible tablet, to be dispersed in 10 ml water
Dosage
- Child under 30 kg: 35 mg/kg (30 to 40 mg/kg) once daily
- Child 30 kg and over and adult: 25 mg/kg (20 to 30 mg/kg) once daily
- Maximum dose: 2000 mg daily
- Renal insufficiency: 25 mg/kg 3 times a week
|
Weight |
Daily dose |
400 mg |
150 mg |
|---|---|---|---|
|
5 |
150-200 |
– |
1 tab |
|
6 |
180-240 |
– |
1 tab |
|
7 |
210-280 |
– |
2 tab |
|
8 |
240-320 |
– |
2 tab |
|
9 |
270-360 |
– |
2 tab |
|
10 |
300-400 |
– |
3 tab |
|
11 |
330-440 |
– |
3 tab |
|
12 |
360-480 |
– |
3 tab |
|
13 |
390-520 |
– |
3 tab |
|
14 |
420-560 |
– |
3 tab |
|
15 |
450-600 |
– |
3 tab |
|
16 |
480-640 |
– |
4 tab |
|
17 |
510-680 |
– |
4 tab |
|
18 |
540-720 |
– |
4 tab |
|
19 |
570-760 |
– |
4 tab |
|
20 |
600-800 |
– |
5 tab |
|
21 |
630-840 |
– |
5 tab |
|
22 |
660-880 |
– |
5 tab |
|
23 |
690-920 |
– |
5 tab |
|
24 |
720-960 |
2½ tab |
– |
|
25 |
750-1000 |
2½ tab |
– |
|
26 |
780-1040 |
2½ tab |
– |
|
27 |
810-1080 |
2½ tab |
– |
|
28 |
840-1120 |
2½ tab |
– |
|
29 |
870-1160 |
2½ tab |
– |
|
|
|||
|
30-35 |
800 |
2 tab |
– |
|
36-45 |
1000 |
2½ tab |
– |
|
46-55 |
1200 |
3 tab |
– |
|
56-70 |
1600 |
4 tab |
– |
|
> 70 |
2000 |
5 tab |
– |
Contra-indications, adverse effects, precautions
- Do not administer to patients with severe hepatic impairment or severe gout.
- May cause:
- gout and arthralgias;
- hepatotoxicity, gastrointestinal disturbances (epigastric pain, nausea and vomiting);
- hypersensitivity reactions;
- rarely, photosensitivity.
- For the management of adverse effects, see Appendix 17.
- Pregnancy: no contra-indication
- Breastfeeding: no contra-indication
Monitoring
- Symptomatic monitoring.
- Liver function in patients with hepatic impairment or on drug-resistant TB treatment.
Patient instructions
- Take with or without food.
- 150 mg tablets should be dispersed in 10 ml water.
- Protect your skin from sun.
Remarks
- For patients on drug-susceptible TB treatment, pyrazinamide is given as part of a fixed-dose combination.
- For the 6HRZEto regimen for drug-susceptible TB meningitis, the dose of pyrazinamide is 40 mg/kg once daily (max. 2000 mg daily).
Storage
–
– Below 25 °C