Para-aminosalicylate sodium (PAS)

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Update: October 2022

Powder for oral solution, 5.52 g sachet of para-aminosalicylate sodium (equivalent to 4 g PAS acid), to be dissolved in 100 ml water

Weight (kg)	Daily dose (mg)	Oral solution or sachet PAS sodium
5	1000-1500	19 ml x 2
6	1200-1800	19 ml x 2
7	1400-2100	25 ml x 2
8	1600-2400	25 ml x 2
9	1800-2700	25 ml x 2
10	2000-3000	50 ml x 2
11	2200-3300	50 ml x 2
12	2400-3600	50 ml x 2
13	2600-3900	50 ml x 2
14	2800-4200	50 ml x 2
15	3000-4500	50 ml x 2
16	3200-4800	75 ml x 2
17	3400-5100	75 ml x 2
18	3600-5400	75 ml x 2
19	3800-5700	75 ml x 2
20	4000-6000	75 ml x 2
21	4200-6300	75 ml x 2
22	4400-6600	75 ml x 2
23	4600-6900	75 ml x 2
24	4800-7200	80 ml x 2
25	5000-7500	80 ml x 2
26	5200-7800	80 ml x 2
27	5400-8000	80 ml x 2
28	5600-8000	80 ml x 2
29	5800-8000	80 ml x 2

30-70	8 g	1 sachet x 2
> 70	8-12 g	1 to 1½ sachet x 2

Avoid in patients with severe renal disease.
Avoid or use with caution in patients with hepatic impairment or gastric ulcer.
May cause :
- frequent gastrointestinal disturbances (nausea, vomiting, gastritis, diarrhoea);
- hypothyroidism, hepatotoxicity, hypersensitivity reactions.
Monitor combination with ethionamide/prothionamide (increased risk of gastrointestinal disturbances and hypothyroidism).
For the management of adverse effects, see Apendix 17.
Pregnancy: use only if benefits outweigh the risks (safety not established).
Breastfeeding: avoid breastfeeding during treatment (safety not established).

To increase gastrointestinal tolerance, start with a low dose, e. g. for an adult : 2 g 2 times daily for 1 to 2 weeks, then 4 g 2 times daily.

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– Below 25 °C