Moxifloxacin (Mfx)

Therapeutic action

– Antibacterial (fluoroquinolone) with bactericidal activity

Presentation

– 400 mg tablet

Dosage

– Child under 30 kg: 7.5 to 10 mg/kg once daily
– Child over 30 kg and adult: 400 mg once daily
– Maximum dose: 400 mg daily

Weight
(kg)

Daily dose
(mg)

400 mg
tablet

5

37.5-50

6

45-60

7

52.5-70

8

60-80

9

67.5-90

10

75-100

¼ tab

11

82.5-110

¼ tab

12

90-120

¼ tab

13

97.5-130

¼ tab

14

105-140

¼ tab

15

112.5-150

¼ tab

16

120-160

¼ tab

17

127.5-170

¼ tab

18

135-180

½ tab

19

142.5-190

½ tab

20

150-200

½ tab

21

157.5-210

½ tab

22

165-220

½ tab

23

172.5-230

½ tab

24

180-240

½ tab

25

187.5-250

½ tab

26

195-260

½ tab

27

202.5-270

½ tab

28

210-280

½ tab

29

217.5-290

½ tab


30-35

400

1 tab

36-45

400

1 tab

46-55

400

1 tab

56-70

400

1 tab

> 70

400

1 tab

Contra-indications, adverse effects, precautions

– Do not administer to patients with history of allergy or tendon damage during a previous treatment with a fluoroquinolone.
– Administer with caution to children, adolescents and patients over 60 years (increased risk of tendon damage); patients with risk factors for QT interval prolongation (heart failure, bradycardia, hypokalaemia, etc.) or history of psychiatric disorders or seizures.
– May cause: gastrointestinal disturbances, headache, central nervous system disorders (dizziness, insomnia, depression, etc.), hypersensitivity reactions, photosensitivity, peripheral neuropathy, myalgia, tendinitis, tendon rupture, QT prolongation; rarely, crystalluria.
– For the management of adverse effects see Appendix 10.
– Avoid or monitor combination with drugs that prolong QT interval (amiodarone, bedaquiline, clofazimine, erythromycin, fluconazole, lopinavir, mefloquine, ondansetron, pentamidine, quinine, etc.) and warfarin.
– Do not administer simultaneously with antacids containing magnesium or aluminium, calcium, iron and zinc salts, didanosine (except enteric-coated formulation): administer 2 hours apart.
Pregnancy and breastfeeding: safety is not established, considered as acceptable when vital for the mother.

Monitoring

– Symptomatic monitoring

Patient instructions

– May be taken with food but do not take milk-based product and antacids and multivitamins when taking a tablet, wait two hours.
– Maintain a good fluid intake.
– Protect your skin from sun.

Remarks

– Moxifloxacin is more frequently associated with QT prolongation than levofloxacin and ofloxacin.
 Storage: below 25°C -