INACTIVATED POLIOMYELITIS VACCINE (IPV)

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    Indications

    • Prevention of poliomyelitis, alone or in combination with the oral poliomyelitis vaccine (bOPV)

    Composition, forms, route of administration

    • Inactivated virus vaccine, trivalent (poliovirus types 1, 2 and 3)
    • Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years or deep SC injection into the deltoid muscle in children ≥ 2 years and adults

    Dosage and vaccination schedule

    • bOPV + IPV schedule
      Child: 0.5 ml single dose at 14 weeks, in combination with a dose of bOPV
    • IPV only schedule
      Child: 3 doses of 0.5 ml approximately 4 weeks apart, at 6, 10 and 14 weeks of age and a booster dose at least 6 months after the 3rd dose

    Contra-indications, adverse effects, precautions

    • Vaccination should be postponed in the event of severe acute febrile illness (minor infections are not contra-indications).
    • May cause: mild local reaction (pain, redness at the injection site), fever; exceptionally, anaphylactic reaction.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Protection against poliomyelitis lasts for life after 4 doses.
    • In children who start routine vaccination late (after the age of 3 months), the dose of IPV is administered together with the 1st dose of bOPV, followed by 2 doses of bOPV alone administered 4 weeks apart.
    • If there is a shortage of IPV the intradermal route is an alternative, if the operator is experienced in this administration technique. The vaccination schedule is: 2 doses of 0.1 ml at 6 and 14 weeks of age (the 2 doses must be administered at least 4 weeks apart).
    • Certain countries have vaccination schedules for children and adults that use only the injectable vaccine and include booster doses: follow national recommendations.

    Storage

     
    –  Between 2 °C and 8 °C. Do not freeze.