TYPHOID CONJUGATE VACCINE (TCV)

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    Indications

    • Prevention of typhoid fever in children as of 6 months and adults up to 45 years of age:
      • in endemic areas
      • in mass immunisation campaigns in the event of an outbreak or humanitarian emergency context, based on risk assessment 

    Composition, forms, route of administration

    • Typhoid (polysaccharide) conjugate vaccine
    • Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children ≥ 2 years. 
      DO NOT ADMINISTER INTO THE GLUTEAL MUSCLE.

    Dosage and vaccination schedule

    Child and adult: 0.5 ml single dose

     

    Routine vaccination

    • Child at 9 months or during the 2nd year of life:
      one single dose at the same time as other recommended vaccines. Follow national recommendations.

     

    Catch-up vaccination

    • Child up to 15 years:
      one single dose. Follow national recommendations.

    Contra-indications, adverse effects, precautions

    • Do not administer in case of allergic reactions to any component of the vaccine.
    • Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
    • May cause: mild reactions at the injection site (pain, redness at the injection site), fever, headache, myalgia; rarely: anaphylactic reactions.
    • If administered simultaneously with other vaccines, use different syringes and injection sites. 
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Typhoid conjugate vaccine does not protect against Salmonella Paratyphi or other types of non-typhi salmonella.
    • Shake before use to homogenise the vaccine.

    Storage

     
    –  Between 2 °C and 8 °C. Do not freeze.
    Once opened, store vial between 2 °C and 8 °C for 6 hours maximum.