TYPHOID CONJUGATE VACCINE (TCV)

Indications

• Prevention of typhoid fever in children as of 6 months and adults up to 45 years of age:
  • in endemic areas
  • in mass immunisation campaigns in the event of an outbreak or humanitarian emergency context, based on risk assessment 

Composition, forms, route of administration

• Typhoid (polysaccharide) conjugate vaccine
• Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children ≥ 2 years. 
  DO NOT ADMINISTER INTO THE GLUTEAL MUSCLE.

Dosage and vaccination schedule

Child and adult: 0.5 ml single dose

Routine vaccination

• Child at 9 months or during the 2^nd year of life:
  one single dose at the same time as other recommended vaccines. Follow national recommendations.

Catch-up vaccination

• Child up to 15 years:
  one single dose. Follow national recommendations.

Contra-indications, adverse effects, precautions

• Do not administer in case of allergic reactions to any component of the vaccine.
• Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
• May cause: mild reactions at the injection site (pain, redness at the injection site), fever, headache, myalgia; rarely: anaphylactic reactions.
• If administered simultaneously with other vaccines, use different syringes and injection sites. 
• Pregnancy: no contra-indication
• Breast-feeding: no contra-indication

Remarks

• Typhoid conjugate vaccine does not protect against Salmonella Paratyphi or other types of non-typhi salmonella.
• Shake before use to homogenise the vaccine.

Storage