– Prevention of tetanus, diphtheria, pertussis, hepatitis B and severe Haemophilus influenzae type B infections in children from 6 weeks to 7 years of age (primary vaccination)
Composition, forms, route of administration
– Pentavalent vaccine combining tetanus toxoid, diphtheria toxoid, whole-cell pertussis toxoid, recombinant adsorbed hepatitis B vaccine and Haemophilus influenzae type B polysaccharide
– Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children ≥ 2 years. DO NOT ADMINISTER INTO THE GLUTEAL MUSCLE.
Dosage and vaccination schedule
– Neonate: 3 doses 4 weeks apart, preferably before the age of 6 months. It is recommended to administer the 1st dose at 6 weeks of age, the 2nd dose at 10 weeks of age and the 3rd dose at 14 weeks of age.
– If a child has not received the 1st dose by the age of 1 year, start vaccination as soon as possible according to the 0-1-6 schedule:
2 doses 4 weeks apart, then a 3rd dose 6 months after the 1st dose
Contra-indications, adverse effects, precautions
– Do not administer in the event of allergic reactions to a previous dose of vaccine containing these strains.
– Do not administer at birth to vaccinate against hepatitis B.
– Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
– May cause: mild local reactions (redness, pain at the injection site), fever, pain, malaise, headache, myalgia; rarely: anaphylactic reactions.
– If administered simultaneously with other vaccines, use different syringes and injection sites.
– Also comes in:
• a trivalent vaccine (diphtheria, tetanus, pertussis) and tetravalent vaccine (diphtheria, tetanus, pertussis, hepatitis B) used for primary vaccination in children < 7 years;
• a bivalent Td vaccine containing a reduced dose of diphtheria toxoid (tetanus-diphtheria), used in children ≥ 4 years, adolescents and adults.
– Storage: between 2 °C and 8 °C. Do not freeze –