– Prevention of hepatitis B

Composition, forms, route of administration

– Recombinant hepatitis B vaccine 
– Suspension for injection in monodose or multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children ≥ 2 years. DO NOT ADMINISTER INTO THE GLUTEAL MUSCLE.

Dosage and vaccination schedule

Dosage varies according to age and type of vaccine used: follow manufacturer's instructions.
Child: one dose = 5 to 10 micrograms
Adult: one dose = 10 to 20 micrograms

 Standard schedule
 Neonate and infant:
One dose as soon as possible after birth (preferably within the first 24 hours of life) then a 2nd dose at 6 weeks and a 3rd dose at 14 weeks
One dose as soon as possible after birth (preferably within the first 24 hours of life) then 3 doses administered 4 weeks apart with the 1st at 6 weeks, the 2nd at 10 weeks and the 3rd at 14 weeks
• Child, adolescent, adult: schedule 0-1-6
2 doses 4 weeks apart, then a 3rd dose 6 months after the 1st dose

– Accelerated schedule, when rapid protection is required in the event of post-exposure prophylaxis
3 doses administered during the same month on D0-D7-D21, then a 4th dose one year after the 1st dose

Contra-indications, adverse effects, precautions

– Do not administer in the event of allergic reactions to a previous dose of hepatitis B vaccine. 
– Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
– May cause: minor local reactions (pain or redness at injection site), fever, headache, myalgia;  rarely: anaphylactic reaction.
– If administered simultaneously with other vaccines, use different syringes and injection sites.
– Pregnancy and breast-feedingno contra-indication


– At birth, use only the monovalent hepatitis B vaccine. For the following doses, administer a monovalent or tetravalent (diphtheria, tetanus, pertussis, hepatitis B) or pentavalent (diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae) vaccine.
– If an infant was not administered the birth dose, this dose can be administered at anytime during the first contact with health-care providers, up to the time of the next dose of the primary schedule.
– If the vaccination schedule is interrupted before the complete series has been administered, it is not necessary to start again from the beginning. Continue the vaccination schedule from where it was interrupted and complete the series as normal.
– SC route may be used, only if IM route is contra-indicated.
– Shake before use to homogenise the vaccine.
– Storage: between 2 °C and 8 °C. Do not freeze -