HUMAN TETANUS IMMUNOGLOBULIN (HTIG)



Therapeutic action

– Neutralisation of tetanus toxin. HTIG provides passive immunization against tetanus for 3 to 4 weeks.

Indications

– Prevention of tetanus in wound management, in patients non immunised or incompletely immunised or in patients whose immunisation status is unknown, in combination with tetanus vaccine
– Treatment of clinical tetanus

Forms and strengths, route of administration

– Solution for injection, in 250 IU (250 IU/ml, 1 ml) or 500 IU (250 IU/ml, 2 ml) ampoule or single-dose syringe, for IM injection. DO NOT ADMINISTER BY IV ROUTE.

Dosage and duration

– Prevention of tetanus
HTIG is administered in the event of tetanus-prone wounds, e.g. wounds with fracture, deep penetrating wounds, bite wounds, wounds containing foreign bodies, wounds contaminated with soil, infected wounds, extensive tissue damage (contusions, burns).
Child and adult: 250 IU single dose; 500 IU if more than 24 hours has elapsed
HTIG should be administered as soon as possible after injury, along with the tetanus vaccine, in a separate syringe and injection site.

– Treatment of tetanus
Neonate, child and adult: 500 IU single dose, to be injected into 2 different sites

Contra-indications, adverse effects, precautions

– Do not administer to patients with known allergy to HTIG.
– May cause (very rarely): allergic reactions.
– Ensure that the HTIG does not enter a blood vessel (risk of shock): aspirate prior to injection to confirm that the needle is not in a vein.
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– For minor clean wounds, tetanus vaccine is administered alone.
– SC route may be used but only if IM route is contra-indicated.
– Storage: between 2 °C and 8 °C. Do not freeze -