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Update: October 2022
Forms and strengths
- Powder for oral solution, 5.52 g sachet of para-aminosalicylate sodium (equivalent to 4 g PAS acid), to be dissolved in 100 ml water
Dosage (expressed in PAS acid)
- Child under 30 kg: 100 to 150 mg/kg 2 times daily
- Child 30 kg and over and adult: 4 g 2 times daily (max. 12 g daily)
Weight |
Daily dose |
Oral solution or sachet PAS sodium |
---|---|---|
5 |
1000-1500 |
19 ml x 2 |
6 |
1200-1800 |
19 ml x 2 |
7 |
1400-2100 |
25 ml x 2 |
8 |
1600-2400 |
25 ml x 2 |
9 |
1800-2700 |
25 ml x 2 |
10 |
2000-3000 |
50 ml x 2 |
11 |
2200-3300 |
50 ml x 2 |
12 |
2400-3600 |
50 ml x 2 |
13 |
2600-3900 |
50 ml x 2 |
14 |
2800-4200 |
50 ml x 2 |
15 |
3000-4500 |
50 ml x 2 |
16 |
3200-4800 |
75 ml x 2 |
17 |
3400-5100 |
75 ml x 2 |
18 |
3600-5400 |
75 ml x 2 |
19 |
3800-5700 |
75 ml x 2 |
20 |
4000-6000 |
75 ml x 2 |
21 |
4200-6300 |
75 ml x 2 |
22 |
4400-6600 |
75 ml x 2 |
23 |
4600-6900 |
75 ml x 2 |
24 |
4800-7200 |
80 ml x 2 |
25 |
5000-7500 |
80 ml x 2 |
26 |
5200-7800 |
80 ml x 2 |
27 |
5400-8000 |
80 ml x 2 |
28 |
5600-8000 |
80 ml x 2 |
29 |
5800-8000 |
80 ml x 2 |
|
||
30-70 |
8 g |
1 sachet x 2 |
> 70 |
8-12 g |
1 to 1½ sachet x 2 |
Contra-indications, adverse effects, precautions
- Avoid in patients with severe renal disease.
- Avoid or use with caution in patients with hepatic impairment or gastric ulcer.
- May cause :
- frequent gastrointestinal disturbances (nausea, vomiting, gastritis, diarrhoea);
- hypothyroidism, hepatotoxicity, hypersensitivity reactions.
- Monitor combination with ethionamide/prothionamide (increased risk of gastrointestinal disturbances and hypothyroidism).
- For the management of adverse effects, see Apendix 17.
- Pregnancy: use only if benefits outweigh the risks (safety not established).
- Breastfeeding: avoid breastfeeding during treatment (safety not established).
Monitoring
- Symptomatic monitoring.
- Liver and thyroid function.
Patient instructions
- Mix the powder with 100 ml water.
- Take with food to limit gastrointestinal disturbances.
Remarks
- To increase gastrointestinal tolerance, start with a low dose, e. g. for an adult : 2 g 2 times daily for 1 to 2 weeks, then 4 g 2 times daily.
Storage
–
– Below 25 °C