AMODIAQUINE = AQ oral

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    Prescription under medical supervision

     

    Do not administer the combination artesunate-amodiaquine as separate tablets (i.e. artesunate tablets + amodiaquine tablets). Use co-formulated tablets.

     

     Therapeutic action

    • Antimalarial

    Indications

    • Treatment of uncomplicated falciparum malaria, in combination with artesunate
    • Treatment of uncomplicated malaria due to other Plasmodium species, in combination with artesunate, when chloroquine cannot be used
    • Completion treatment following parenteral therapy for severe malaria, in combination with artesunate

    Forms and strengths

    • 200 mg amodiaquine hydrochloride tablet, containing 153 mg amodiaquine base

    Dosage and duration

    • Child and adult: 10 mg base/kg once daily for 3 days, in combination with artesunate

    Contra-indications, adverse effects, precautions

    • Do not administer in the event of previous severe adverse reaction to treatment with amodiaquine (e.g. hypersensitivity reaction, hepatitis, leucopenia, agranulocytosis).
    • Do not administer to patients taking efavirenz.
    • May cause: gastrointestinal disturbances, pruritus, cough, insomnia.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Remarks

    • Also comes as co-packaged dispersible tablets for seasonal malaria chemoprevention in children: amodiaquine 153 mg + sulfadoxine/pyrimethamine 500 mg/25 mg and amodiaquine 76.5 mg + sulfadoxine/pyrimethamine 250 mg/12.5mg.

    Storage

     
    – Below 25 °C