SALBUTAMOL = ALBUTEROL injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Uterine relaxant

    Indications

    • Threatened premature labour (preferably use nifedipine for this indication)

    Forms and strengths, route of administration

    • 0.5 mg in 1 ml ampoule (0.5 mg/ml) for IV infusion

    Dosage

    • Dilute 5 mg (10 ampoules of 0.5 mg) in 500 ml of 5% glucose or 0.9% sodium chloride to obtain a solution of 10 micrograms/ml.
    • Start infusion at the rate of 15 to 20 micrograms/minute (30 to 40 drops/minute).
    • If contractions persist, increase the rate by 10 to 20 drops/minute every 30 minutes until uterine contractions cease. Do not exceed 45 micrograms/minute (90 drops/minute).
    • Continue for one hour after contractions have ceased, then reduce the rate by half every 6 hours.

    Duration

    • 48 hours maximum

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with pre-eclampsia, eclampsia, uterine haemorrhage, intra- uterine infection, intra-uterine foetal death, placenta praevia, placental abruption, rupture of membranes, multiple pregnancy, severe cardiopathy.
    • Administer with caution to patients with diabetes, hyperthyroidism.
    • Do not combine with nifedipine.
    • May cause: pulmonary oedema, myocardial ischemia, foetal and maternal tachycardia, hypotension, tremor, headache, hypokalaemia, hyperglycaemia.
    • Monitor maternal pulse regularly. Reduce the infusion rate in the event of maternal tachycardia (> 120/minute).
    • Pregnancy: no contra-indication
    • Breast-feeding: avoid

    Remarks

    • Use salbutamol within 24 hours of mixing with infusion fluid.
    • Do not mix with other drugs in the same infusion fluid.
    • Also comes in 5 ml ampoule containing 0.25 mg (0.05 mg/ml).

    Storage

     
    –  Below 25 °C