ARTEMETHER injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Antimalarial

    Indications

    • Alternative to injectable artesunate (when it is not available) in the:
      • Treatment of severe malaria
      •  Initial treatment of uncomplicated malaria, when persistent vomiting precludes oral therapy

    Forms and strengths, route of administration

    • 80 mg in 1 ml ampoule (80 mg/ml), oily solution for IM injection. NEVER ADMINISTER BY IV ROUTE.

    When the dose required is less than 1 ml, use a 1 ml syringe graduated in 0.01 ml.

    Dosage and duration

    • Child and adult:

    3.2 mg/kg by IM injection on the first day followed by 1.6 mg/kg once daily

     

    Weight 80 mg ampoule
    Loading dose Maintenance dose

    3-4 kg

    0.2 ml

    0.1 ml

    5-6 kg

    0.3 ml

    0.15 ml

    7-9 kg

    0.4 ml

    0.2 ml

    10-14 kg

    0.6 ml

    0.3 ml

    15-19 kg

    0.8 ml

    0.4 ml

    20-29 kg

    1.2 ml

    0.6 ml

    30-39 kg

    1.6 ml

    0.8 ml

    40-49 kg

    2 ml

    1 ml

    50-59 kg

    2.5 ml

    1.2 ml

     

    • Treat parenterally for at least 24 hours (2 doses), then, if the patient can tolerate the oral route, change to a complete 3-day course of an artemisinin-based combination. If not, continue parenteral treatment once daily until the patient can change to oral route (without exceeding 7 days of parenteral treatment).

    Contra-indications, adverse effects, precautions

    • May cause: gastrointestinal disturbances, dizziness.
    • Pregnancy: no contra-indication
    • Breast-feeding: no contra-indication

    Storage

     
    – Below 25 °C