Long-acting oily CHLORAMPHENICOL injectable

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    Prescription under medical supervision

     

    Therapeutic action

    • Phenicol antibacterial, with prolonged effect

    Indications

    • Treatment of meningococcal meningitis during epidemics

    Forms and strengths, route of administration

    • 500 mg oily suspension in 2 ml ampoule (250 mg/ml) for IM injection only. NEVER FOR IV INJECTION.

    Dosage

    • Child over 2 years and adult: 100 mg/kg single dose (max. 3 g per dose)

     

    Age

    Weight

    Dose

    Volume

    2 to < 6 years

    13 to < 21 kg

    1.5 g

    6 ml

    6 to < 10 years

    21 to < 31 kg

    2 g

    8 ml

    10 to < 15 years

    31 to < 54 kg

    2.5 g

    10 ml

    ≥ 15 years and adult

    ≥ 54 kg

    3 g

    12 ml

     

    • If necessary, administer half the dose into each buttock.

    Duration

    • Single dose. If there is no improvement after 24 hours, a second dose may be administered.

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with:
      • history of allergic reaction or bone marrow depression during a previous treatment with chloramphenicol;
      • G6PD deficiency.
    • May cause:
      • dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia, thrombocytopenia), allergic reactions. In these events, stop treatment immediately;
      • gastrointestinal disturbances, peripheral and optic neuropathies.
    • Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine, co-trimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
    • Pregnancy: CONTRA-INDICATED
    • Breast-feeding: CONTRA-INDICATED

    Remarks

    • Oily chloramphenicol is not recommended as chemoprophylaxis for meningitis contacts during epidemics.
    • Shake the injection suspension before administration.

    Storage

     
    – Below 25 °C