Long-acting oily CHLORAMPHENICOL injectable

Select language:
Permalink

 

 
Prescription under medical supervision

 

Therapeutic action

  • Phenicol antibacterial, with prolonged effect

Indications

  • Treatment of meningococcal meningitis during epidemics

Forms and strengths, route of administration

  • 500 mg oily suspension in 2 ml ampoule (250 mg/ml) for IM injection only. NEVER FOR IV INJECTION.

Dosage

  • Child over 2 years and adult: 100 mg/kg single dose (max. 3 g per dose)

 

Age

Weight

Dose

Volume

2 to < 6 years

13 to < 21 kg

1.5 g

6 ml

6 to < 10 years

21 to < 31 kg

2 g

8 ml

10 to < 15 years

31 to < 54 kg

2.5 g

10 ml

≥ 15 years and adult

≥ 54 kg

3 g

12 ml

 

  • If necessary, administer half the dose into each buttock.

Duration

  • Single dose. If there is no improvement after 24 hours, a second dose may be administered.

Contra-indications, adverse effects, precautions

  • Do not administer to patients with:
    • history of allergic reaction or bone marrow depression during a previous treatment with chloramphenicol;
    • G6PD deficiency.
  • May cause:
    • dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia, thrombocytopenia), allergic reactions. In these events, stop treatment immediately;
    • gastrointestinal disturbances, peripheral and optic neuropathies.
  • Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine, co-trimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
  • Pregnancy: CONTRA-INDICATED
  • Breast-feeding: CONTRA-INDICATED

Remarks

  • Oily chloramphenicol is not recommended as chemoprophylaxis for meningitis contacts during epidemics.
  • Shake the injection suspension before administration.

Storage

 
– Below 25 °C