ARTESUNATE + SULFADOXINE/PYRIMETHAMINE = AS + SP oral

Select language:
On this page

     

    Prescription under medical supervision

     

    Therapeutic action

    • Antimalarial

    Indications

    • Treatment of uncomplicated falciparum malaria
    • Completion treatment following parenteral therapy for severe falciparum malaria

    Forms and strengths

    • Artesunate (AS) tablets and sulfadoxine/pyrimethamine (SP) tablets, in blister packs, for a complete treatment for one individual
    • There are 4 different blister packs:
      • Child < 25 kg:
        blister pack with 3 tab AS 50 mg and 1 tab SP 500/25 mg
      • Child 25 to < 50 kg:
        blister pack with 6 tab AS 50 mg and 2 tab SP 500/25 mg
      • Child ≥ 50 kg and adult:
        blister pack with 12 tab AS 50 mg and 3 tab SP 500/25 mg
        or blister pack with 6 tab AS 100 mg and 3 tab SP 500/25 mg

    Dosage and duration

    • Artesunate is administered once daily for 3 days.
      Sulfadoxine/pyrimethamine is administered as a single dose on D1, with the first dose of artesunate.

     

    Weight

    Blister pack

    D1

    D2

    D3

    5 to < 10 kg

    3 tab AS50 + 1 tab SP

    ½ tab AS + ½ tab SP

    ½ tab AS

    ½ tab AS

    10 to < 25 kg

    3 tab AS50 + 1 tab SP

    1 tab AS + 1 tab SP

    1 tab AS

    1 tab AS

    25 to < 50 kg

    6 tab AS50 + 2 tab SP

    2 tab AS + 2 tab SP

    2 tab AS

    2 tab AS

    ≥ 50 kg and adult

    12 tab AS50 + 3 tab SP

    4 tab AS + 3 tab SP

    4 tab AS

    4 tab AS

    6 tab AS100 + 3 tab SP

    2 tab AS + 3 tab SP

    2 tab AS

    2 tab AS

     

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to sulfonamides.
    • May cause: see artesunate and sulfadoxine/pyrimethamine.
    • Do not use in combination with co-trimoxazole.
    • Do not give folic acid on the same day SP is administered, or within 2 weeks thereafter.
    • Pregnancy: CONTRA-INDICATED during the first trimester (risk of neural tube defects); no contra-indication during the 2nd and 3rd trimester
    • Breast-feeding: no contra-indication

    Storage

     
    – 
     
    – Below 30 °C
    Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered immediately.
    If half tablets are used, remaining half tablets may be given to another patient if administered within 24 hours.