ARTESUNATE + SULFADOXINE/PYRIMETHAMINE = AS + SP oral

Select language:
Enter
Permalink
Download
Comment
Return to top
On this page

     

    Prescription under medical supervision

     

    Therapeutic action

    • Antimalarial

    Indications

    • Treatment of uncomplicated falciparum malaria
    • Completion treatment following parenteral therapy for severe falciparum malaria

    Forms and strengths

    • Artesunate (AS) tablets and sulfadoxine/pyrimethamine (SP) tablets, in blister packs, for a complete treatment for one individual
    • There are 4 different blister packs:
      • Child < 25 kg:
        blister pack with 3 tab AS 50 mg and 1 tab SP 500/25 mg
      • Child 25 to < 50 kg:
        blister pack with 6 tab AS 50 mg and 2 tab SP 500/25 mg
      • Child ≥ 50 kg and adult:
        blister pack with 12 tab AS 50 mg and 3 tab SP 500/25 mg
        or blister pack with 6 tab AS 100 mg and 3 tab SP 500/25 mg

    Dosage and duration

    • Artesunate is administered once daily for 3 days.
      Sulfadoxine/pyrimethamine is administered as a single dose on D1, with the first dose of artesunate.

     

    Weight

    Blister pack

    D1

    D2

    D3

    5 to < 10 kg

    3 tab AS50 + 1 tab SP

    ½ tab AS + ½ tab SP

    ½ tab AS

    ½ tab AS

    10 to < 25 kg

    		 3 tab AS50 + 1 tab SP

    1 tab AS + 1 tab SP

    1 tab AS

    1 tab AS

    25 to < 50 kg

    6 tab AS50 + 2 tab SP

    2 tab AS + 2 tab SP

    2 tab AS

    2 tab AS

    ≥ 50 kg and adult

    12 tab AS50 + 3 tab SP

    4 tab AS + 3 tab SP

    4 tab AS

    4 tab AS

    6 tab AS100 + 3 tab SP

    2 tab AS + 3 tab SP

    2 tab AS

    2 tab AS

     

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with allergy to sulfonamides.
    • May cause: see artesunate and sulfadoxine/pyrimethamine.
    • Do not use in combination with co-trimoxazole.
    • Do not give folic acid on the same day SP is administered, or within 2 weeks thereafter.
    • Pregnancy: CONTRA-INDICATED during the first trimester (risk of neural tube defects); no contra-indication during the 2nd and 3rd trimester
    • Breast-feeding: no contra-indication

    Storage

     
    – 
     
    – Below 30 °C
    Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered immediately.
    If half tablets are used, remaining half tablets may be given to another patient if administered within 24 hours.

     

    Path