ARTEMETHER injectable

Prescription under medical supervision


Therapeutic action

– Antimalarial

Indications

– Alternative to injectable artesunate (when it is not available) in the:
• Treatment of severe malaria
• Initial treatment of uncomplicated malaria, when persistent vomiting precludes oral therapy

Forms and strengths, route of administration

– 80 mg in 1 ml ampoule (80 mg/ml), oily solution for IM injection. NEVER ADMINISTER BY IV ROUTE.
When the dose required is less than 1 ml, use a 1 ml syringe graduated in 0.01 ml.

Dosage and duration

– Child and adult:
3.2 mg/kg by IM injection on the first day followed by 1.6 mg/kg once daily


Weight
80 mg ampoule

Loading dose

maintenance dose

3-4 kg

0.2 ml

0.1 ml

5-6 kg

0.3 ml

0.15 ml

7-9 kg

0.4 ml

0.2 ml

10-14 kg

0.6 ml

0.3 ml

15-19 kg

0.8 ml

0.4 ml

20-29 kg

1.2 ml

0.6 ml

30-39 kg

1.6 ml

0.8 ml

40-49 kg

2 ml

1 ml

50-59 kg

2.5 ml

1.2 ml

– Treat parenterally for at least 24 hours (2 doses), then, if the patient can tolerate the oral route, change to a complete 3-day course of an artemisinin-based combination. If not, continue parenteral treatment once daily until the patient can change to oral route (without exceeding 7 days of parenteral treatment).

Contra-indications, adverse effects, precautions

– May cause: gastrointestinal disturbances, dizziness.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Storage: below 25 °C -