ARTESUNATE + SULFADOXINE/PYRIMETHAMINE = AS + SP oral

Prescription under medical supervision


Therapeutic action

– Antimalarial

Indications

– Treatment of uncomplicated falciparum malaria
– Completion treatment following parenteral therapy for severe falciparum malaria

Forms and strengths

– Artesunate (AS) tablets and sulfadoxine/pyrimethamine (SP) tablets, in blister packs, for a complete treatment for one individual

– There are 4 different blister packs:
• Child < 25 kg:
   blister pack with 3 tab AS 50 mg and 1 tab SP 500/25 mg
• Child 25 to < 50 kg:
   blister pack with 6 tab AS 50 mg and 2 tab SP 500/25 mg
• Child ≥ 50 kg and adult: 
   blister pack with 12 tab AS 50 mg and 3 tab SP 500/25 mg
   or blister pack with 6 tab AS 100 mg and 3 tab SP 500/25 mg

Dosage and duration

– Artesunate is administered once daily for 3 days. Sulfadoxine/pyrimethamine is administered as a single dose on D1, with the first dose of artesunate.

Weight

Blister pack

D1

D2

D3

5 to < 10 kg


3 tab AS50 + 1 tab SP

½ tab AS + ½ tab SP

½ tab AS

½ tab AS

10 to < 25 kg

1 tab AS + 1 tab SP

1 tab AS

1 tab AS

25 to < 50 kg

6 tab AS50 + 2 tab SP

2 tab AS + 2 tab SP

2 tab AS

2 tab AS


≥ 50 kg and adult

12 tab AS50 + 3 tab SP

4 tab AS + 3 tab SP

4 tab AS

4 tab AS

6 tab AS100 + 3 tab SP

2 tab AS + 3 tab SP

2 tab AS

2 tab AS

Contra-indications, adverse effects, precautions

– Do not administer to patients with allergy to sulfonamides.
– May cause: see artesunate and sulfadoxine/pyrimethamine.
– Do not use in combination with co-trimoxazole.
– Do not give folic acid on the same day SP is administered, or within 2 weeks thereafter.
Pregnancy: CONTRA-INDICATED during the first trimester (risk of neural tube defects); no contra-indication during the 2nd and 3rd trimester
Breast-feeding: no contra-indication

Remarks

  Storage: below 30 °C -  - 
Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered immediately.
If half tablets are used, remaining half tablets may be given to another patient if administered within 24 hours.