Long-acting oily CHLORAMPHENICOL injectable

Prescription under medical supervision

Therapeutic action

– Phenicol antibacterial, with prolonged effect

Indications

– Treatment of meningococcal meningitis during epidemics

Forms and strengths, route of administration

– 500 mg oily suspension in 2 ml ampoule (250 mg/ml) for IM injection only. NEVER FOR IV INJECTION.

Dosage

– Child over 2 years and adult: 100 mg/kg single dose (max. 3 g per dose)

Age

Weight

Dose

Volume

2 to < 6 years

13 to < 21 kg

1.5 g

6 ml

6 to < 10 years

21 to < 31 kg

2 g

8 ml

10 to < 15 years

31 to < 54 kg

2.5 g

10 ml

≥ 15 years and adult

≥ 54 kg

3 g

12 ml

– If necessary, administer half the dose into each buttock.

Duration

– Single dose. If there is no improvement after 24 hours, a second dose may be administered.

Contra-indications, adverse effects, precautions

– Do not administer to patients with:
• history of allergic reaction or bone marrow depression during a previous treatment with chloramphenicol;
• G6PD deficiency.
– May cause:
• dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia, thrombocytopenia), allergic reactions. In these events, stop treatment immediately;
• gastrointestinal disturbances, peripheral and optic neuropathies.
– Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine, co-trimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
– PregnancyCONTRA-INDICATED
– Breast-feedingCONTRA-INDICATED

Remarks

– Oily chloramphenicol is not recommended as chemoprophylaxis for meningitis contacts during epidemics.
– Shake the injection suspension before administration.
– Storage: below 25 °C -