TYPHOID CONJUGATE VACCINE (TCV)


Indications

– Prevention of typhoid fever in children as of 6 months and adults up to 45 years of age:
• in endemic areas
• in mass immunisation campaigns in the event of an outbreak or humanitarian emergency context, based on risk assessment 

Composition, forms, route of administration

– Typhoid (polysaccharide) conjugate vaccine
– Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children ≥ 2 years. DO NOT ADMINISTER INTO THE GLUTEAL MUSCLE.

Dosage and vaccination schedule

– Child and adult: 0.5 ml single dose

– Routine vaccination
Child at 9 months or during the 2nd year of life: one single dose at the same time as other recommended vaccines. Follow national recommendations.

– Catch-up vaccination
Child up to 15 years: one single dose. Follow national recommendations.

Contra-indications, adverse effects, precautions

– Do not administer in case of allergic reactions to any component of the vaccine.
– Vaccination should be postponed in the event of severe acute febrile illness; minor infections are not contra-indications.
– May cause: mild reactions at the injection site (pain, redness at the injection site), fever, headache, myalgia; rarely: anaphylactic reactions.
– If administered simultaneously with other vaccines, use different syringes and injection sites. 
– Pregnancy: no contra-indication
– Breast-feeding: no contra-indication

Remarks

– Typhoid conjugate vaccine does not protect against Salmonella Paratyphi or other types of non-typhi salmonella.
– Shake before use to homogenise the vaccine.
 Storage: between 2 °C and 8 °C. Do not freeze - 
Once opened, store vial between 2 °C and 8 °C for 6 hours maximum.