POTASSIUM CHLORIDE 10% = KCl 10% injectable

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    Prescription under medical supervision

     

    Indications

    • Treatment of severe hypokalaemia (arrhythmia, marked muscular weakness, rhabdomyolysis or serum potassium level ≤ 2.5 mmol/litre)

    Forms and strengths, route of administration

    • Ampoule containing 10% potassium chloride hypertonic solution (100 mg/ml, 10 ml), i.e. 1 g of potassium chloride (KCl) per 10 ml ampoule
    • Ionic composition:
      • potassium (K+): 13.4 mmol per 10 ml ampoule (13.4 mEq)
      • chloride (Cl): 13.4 mmol per 10 ml ampoule (13.4 mEq)
    • Check concentration before use: potassium chloride also comes in ampoules containing 7.5%, 11.2%, 15% and 20% solutions.
    • NEVER USE BY IV OR IM OR SC INJECTION. Potassium chloride must always be administered by slow IV infusion, diluted in 0.9% sodium chloride.
    • For dilution:
      • The potassium concentration in the infusion fluid should not exceed 40 mmol/litre.
      • Mix thoroughly the potassium and the 0.9% sodium chloride solution by inverting at least 5 times the infusion bottle or bag.

    Dosage and duration

    Dosage depends on the severity of hypokalaemia and the patient’s underlying condition. For information:

     

    • Child over 1 month: 0.2 mmol/kg/hour for 3 hours

    Each mmol of potassium is diluted in 25 ml of 0.9% sodium chloride.
    Examples:

     

    10 kg

    0.2 (mmol) x 10 (kg) = 2 mmol/hour x 3 hours = 6 mmol
    6 mmol (= 4.5 ml of 10% KCl solution) diluted in 150 ml of NaCl 0.9% and administered over 3 hours

    15 kg

    0.2 (mmol) x 15 (kg) = 3 mmol/hour x 3 hours = 9 mmol
    9 mmol (= 6.5 ml of 10% KCl solution) diluted in 225 ml of NaCl 0.9% and administered over 3 hours

     

    • Adult: 40 mmol (= 3 ampoules of 10 ml of 10% KCl) in one litre of 0.9% sodium chloride, to be administered over 4 hours. Do not exceed 10 mmol/hour.

     

    The infusion may be repeated if severe symptoms persist or if the serum potassium level remains < 3 mmol/litre.

    Contra-indications, adverse effects, precautions

    • Administer with caution to elderly patients.
    • Administer with caution and reduce the dose in patients with renal impairment (increased risk of hyperkalaemia).
    • May cause:
      • in the event of rapid or excessive administration: hyperkalaemia, cardiac conduction and rhythm disorders, potentially fatal;
      • in the event of extravasation: necrosis.
    • Infusion must be constantly monitored.

    Remarks

    • A 7.5% potassium solution contains 1 mmol of K+/ml; a 11.2% solution contains 1.5 mmol of K+/ml; a 15% solution contains 2 mmol of K+/ml; a 20% solution contains 2.68 mmol of K+/ml.
    • Moderate hypokalaemia is defined as a potassium level < 3.5 mmol/litre; severe hypo kalaemia as a potassium level ≤ 2.5 mmol/litre.

    Storage

    Below 25 °C