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    Prescription under medical supervision


    Therapeutic action

    • Antimalarial


    • Pre-referral treatment of suspected or confirmed severe malaria, in children less than 6 years, before transfer to a facility where parenteral antimalarial treatment can be administered

    Forms and strengths, route of administration

    • 100 mg rectal capsule

    Dosage and duration

    • 10 mg/kg as a single dose before transferring the patient
    • Child 2 months to < 3 years (≤ 10 kg): 1 rectal capsule single dose (100 mg)
    • Child 3 to < 6 years (≤ 20 kg): 2 rectal capsules single dose (200 mg)

    Contra-indications, adverse effects, precautions

    • May cause: gastrointestinal disturbances, headache.
    • Buttocks should be held together for at least 1 minute to ensure retention. If capsules are expelled from the rectum within 30 minutes of insertion, re-administer the treatment.


    • Up to 2 capsules can be administered simultaneously.


    –  Between 15 °C and 25 °C

    Avoid temperature excursions above 30 °C. Do not refrigerate. Do not freeze.