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    Prescription under medical supervision


    Therapeutic action

    • Antibacterial (sulfonamide group)


    • Prophylaxis and treatment of infections of in severe burns
    • Treatment of infections in leg ulcers

    Forms and strengths

    • 1% sterile cream, tube or jar


    • Child 2 months and over and adult: clean the wound then apply a 3 to 5 mm layer of silver sulfadiazine cream to the wound once daily and cover with sterile compresses.


    • Until wound has healed or until skin graft, when required.

    Contra-indications, adverse effects, precautions

    • Do not use in patients with allergy to sulfonamides; in children under 2 months.
    • Do not apply other topical treatments to wounds where silver sulfadiazine is applied.
    • Use with caution in children under 2 years (risk of systemic absorption); in patients with severe renal or hepatic impairment.
    • May cause:
      • skin reactions, grey skin discoloration, skin photosensitivity; rarely: allergic reactions, sometimes severe (Lyell’s and Stevens-Johnson syndromes).
      • systemic adverse effects related to sulfonamides (haematological, renal, cutaneous disorders, etc.) when applied to a large surface area, mucous membranes or prolonged use.
    • Pregnancy: avoid if possible during the 3rd trimester of pregnancy (risk of jaundice in the neonate)
    • Breast-feeding: CONTRA-INDICATED if the child is under one month


    –  Between 8 °C and 25 °C 
    After use, keep the tube or jar tightly closed to avoid exposure to light.