POVIDONE IODINE = POLYVIDONE IODINE = PVI, aqueous solution

Therapeutic action

• Antiseptic and disinfectant

Indications

• Antisepsis of intact or broken skin and mucous membranes
• Disinfection of latex stopper of infusion bottles and drug vials (except vaccines), latex injection sites of infusion sets

Forms and strengths

• 10% aqueous solution

Use

Antisepsis of intact skin (injections, punctures)

• Apply 10% solution to the puncture/injection site and allow to dry before inserting the needle. The skin should be cleaned beforehand if soiled or if the procedure is invasive (lumbar puncture, epidural/spinal anaesthesia, etc.).

Preoperative skin antisepsis

• Apply 10% solution twice. Allow to dry between each application (do not dab to accelerate drying). Incise once the 2^nd application has dried. The surgical site should be cleaned beforehand with PVI scrub solution.

Wound antisepsis

• Apply 10% solution to small superficial wounds.
• For large wounds and burns, wound irrigation, etc., dilute PVI (¼ of 10% PVI and ¾ of 0.9% NaCl or sterile water) then rinse with 0.9% NaCl or sterile water.

Contra-indications, adverse effects, precautions

• Do not use with other antiseptics such as chlorhexidine (incompatibility) or mercury compounds (risk of necrosis).
• Do not use in preterm neonates and neonates < 1.5 kg.
• Due to the risk of transcutaneous resorption of iodine, do not use repeatedly nor on large areas, especially in pregnant and lactating women and infants < 1 month.
• May cause: local skin reactions; exceptionally, allergic reactions.

Remarks

• The antiseptic effect of PVI begins after 30 seconds of contact. However, a minimum contact time of 1 minute is recommended to eliminate bacteria.

Storage