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Therapeutic action
- Antibacterial (sulfonamide group)
Indications
- Prophylaxis and treatment of infections
ofin severe burns - Treatment of infections in leg ulcers
Forms and strengths
- 1% sterile cream, tube or jar
Use
- Child 2 months and over and adult: clean the wound then apply a 3 to 5 mm layer of silver sulfadiazine cream to the wound once daily and cover with sterile compresses.
Duration
- Until wound has healed or until skin graft, when required.
Contra-indications, adverse effects, precautions
- Do not use in patients with allergy to sulfonamides; in children under 2 months.
- Do not apply other topical treatments to wounds where silver sulfadiazine is applied.
- Use with caution in children under 2 years (risk of systemic absorption); in patients with severe renal or hepatic impairment.
- May cause:
- skin reactions, grey skin discoloration, skin photosensitivity; rarely: allergic reactions, sometimes severe (Lyell’s and Stevens-Johnson syndromes).
- systemic adverse effects related to sulfonamides (haematological, renal, cutaneous disorders, etc.) when applied to a large surface area, mucous membranes or prolonged use.
- Pregnancy: avoid if possible during the 3rd trimester of pregnancy (risk of jaundice in the neonate)
- Breast-feeding: CONTRA-INDICATED if the child is under one month
Storage
– Between 8 °C and 25 °C
After use, keep the tube or jar tightly closed to avoid exposure to light.
After use, keep the tube or jar tightly closed to avoid exposure to light.