POVIDONE IODINE = POLYVIDONE IODINE = PVI, aqueous solution



Therapeutic action

– Antiseptic and disinfectant

Indications

– Antisepsis of intact or broken skin and mucous membranes
– Disinfection of latex stopper of infusion bottles and drug vials (except vaccines), latex injection sites of infusion sets

Forms and strengths

– 10% aqueous solution

Use

Antisepsis of intact skin (injections, punctures)
Apply 10% solution to the puncture/injection site and allow to dry before inserting the needle. The skin should be cleaned beforehand if soiled or if the procedure is invasive (lumbar puncture, epidural/spinal anaesthesia, etc.).

Preoperative skin antisepsis
Apply 10% solution twice. Allow to dry between each application (do not dab to accelerate drying). Incise once the 2nd application has dried. The surgical site should be cleaned beforehand with PVI scrub solution.

Wound antisepsis
Apply 10% solution to small superficial wounds.
For large wounds and burns, wound irrigation, etc., dilute PVI (¼ of 10% PVI and ¾ of 0.9% NaCl or sterile water) then rinse with 0.9% NaCl or sterile water.

Contra-indications, adverse effects, precautions

– Do not use with other antiseptics such as chlorhexidine (incompatibility) or mercury compounds (risk of necrosis).
– Do not use in preterm neonates and neonates < 1.5 kg.
– Due to the risk of transcutaneous resorption of iodine, do not use repeatedly nor on large areas, especially in pregnant and lactating women and infants < 1 month.
– May cause: local skin reactions; exceptionally, allergic reactions.

Remarks

– The antiseptic effect of PVI begins after 30 seconds of contact. However, a minimum contact time of 1 minute is recommended to eliminate bacteria.
– Storage: below 25 °C - 
Once the bottle has been opened, solution keeps 30 days.