Select language:
On this page

    Last updated: February 2024


    Prescription under medical supervision


    Therapeutic action

    • Sedating H1 antihistamine


    • Moderate anxiety
    • Insomnia

    Forms and strengths

    • 25 mg tablet


    Moderate anxiety

    • Adult: 25 to 50 mg 2 times daily (max. 100 mg daily)

    Reduce the dose by half in older patients.



    • Adult: 25 mg once daily at bedtime


    • Moderate anxiety: as short as possible (max. 2 weeks)
    • Insomnia: 7 to 10 days

    Contra-indications, adverse effects, precautions

    • Do not administer to patients with closed-angle glaucoma, prostate disorders, dementia, history of QT interval prolongation.
    • Do not combine with drugs that prolong the QT interval (amiodarone, co-artemether, erythromycin, fluconazole, haloperidol, mefloquine, pentamidine, quinine, etc.).
    • Administer with caution (max. 50 mg daily) and monitor use in older patients or patients with hepatic impairment or severe renal impairment.
    • May cause:
      • drowsiness (caution when driving/operating machinery), headache, dizziness;
      • anticholinergic effects (dry mouth, constipation, blurred vision, tachycardia, disorders of micturition);
      • rarely: seizures, QT interval prolongation, allergic reactions.
    • Administer with caution and monitor combination with:
      • central nervous system depressants (opioid analgesics, sedatives, etc.);
      • anticholinergic drugs (atropine, amitriptyline, chlorpromazine, promethazine, etc.).
    • Avoid alcohol during treatment (increased risk of adverse effects).
    • Pregnancy and breast-feeding: avoid


    –  Below 25 °C