TRANEXAMIC acid oral

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    Last updated: October 2021

     

    Prescription under medical supervision

     

    Therapeutic action

    • Antifibrinolytic

    Indications

    • Abnormal uterine bleeding (especially functional uterine bleeding unrelated to pregnancy)

    Forms and strengths

    • 500 mg tablet

    Dosage and duration

    • Adolescent and adult: 1 g 3 times daily (max. 1 g 4 times daily) until bleeding stops (max. 5 days)

    Contra-indications, adverse effects, precautions

    • Do not administer in patients with (or with history of) venous or arterial thromboembolic disorders, severe renal impairment, history of seizures.
    • Reduce dosage in patients with mild to moderate renal impairment (risk of accumulation).
    • May cause: gastrointestinal disturbances, seizures with high doses, visual disturbances, allergic reactions.
    • Avoid combination with drugs that increase the risk of thromboembolism. Concomitant use of oestrogens (e.g. ethinylestradiol/levonorgestrel) should be carefully considered on a case-by-case basis.
    • Pregnancy: this drug is not indicated in the event of bleeding during pregnancy.
    • Breast-feeding: no contra-indication

    Remarks

    • The treatment may be administered at each bleeding episode. In situations of repeated bleeding, it may be helpful to combine tranexamic acid with a non-steroidal anti-inflammatory drug and/or a long-term treatment with a levonorgestrel intrauterine device or ethinylestradiol/levonorgestrel or oral or injectable medroxyprogesterone.

    Storage

    Below 25 °C

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