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- Antiretroviral, HIV nucleotide reverse transcriptase inhibitor
- HIV infection with or without chronic hepatitis B coinfection, in combination with other antiretrovirals
- Chronic hepatitis B without HIV coinfection, in monotherapy
Forms and strengths
- 300 mg tablet, equivalent to 245 mg of tenofovir disoproxil
- Child 35 kg and over and adult: 300 mg once daily
- Depending on the efficacy and tolerance of tenofovir.
Contra-indications, adverse effects, precautions
- Administer with caution and monitor use in patients with renal impairment, osteoporosis. In the event of deterioration of renal function, switch to another antiretroviral.
- Avoid combination (or monitor renal function in the event of combination) with nephrotoxic drugs: aminoglycosides (e.g. gentamicin, streptomycin), amphotericin B, pentamidine, NSAIDs, etc.
- May cause:
- gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.), dizziness, fatigue, skin rash;
- renal impairment, bone loss (osteoporosis, fractures), pancreatitis.
- Pregnancy: no contra-indication
- Tenofovir is also used for HIV pre-exposure and post-exposure prophylaxis, in combination with other antiretrovirals.
- Also comes in fixed-dose combinations containing tenofovir and other antiretrovirals for the treatment of HIV infection. Preferably use these formulations when available.
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